Saturday, July 01, 2006

Hydergine needs more than 3mg per day to be effective (in many cases)

the Anti-aging library has noted this article on hydergine dosage:

HYDERGINE – STILL HIGHLY RECOMMENDED, The World Health Network - Anti-Aging and Longevity
Their assessment was based on their findings that three-mg/ day of Hydergine for six months was ineffective in improving symptoms of eighty patients with Alzheimer's disease. What I think the authors really proved, however, was that three-mg per day is an inadequate dose for Alzheimer's disease (surprise, surprise!).

Previous studies indicated that higher doses were usually required to benefit patients with Alzheimer's disease.
For example, a team of physicians at Stanford University (Yesavage, et al., 1979) administered 6mg of Hydergine each day to 14 hospitalised patients, (aged 62-84) with senile deterioration. All of these patients had been treated for at least 4 months with 3mg Hydergine per day, without noticeable improvement. However, after 12 weeks of treatment at the higher dose, seven of eleven surviving patients, (three of the patients died due to unrelated causes) had shown improvement. One patient, who had been hospitalised for two years, improved so dramatically he was discharged from hospital!

In another study in Japan, Yoshikawa and colleagues (1983) conducted a large double blind study of Hydergine in 550 patients. They found that almost half of the patients in the 6mg group- 48.9%, showed a moderate to marked improvement, compared with only 17.9% in the 3mg group.
Furthermore, they noted that “the superiority of a higher Hydergine dose was particularly pronounced in patients with heavy-headedness, sleep disturbances of various kinds, problems of concentration, loss of vigor, memory disturbances and giddiness.”

They concluded that; “the favourable effects of Hydergine on psychiatric, subjective and neurologic symptoms in patients with cerebrovascular disease are considerably increased when a higher dose is used,” that “a daily dose of 3mg may therefore be insufficient,” and that “clinically relevant improvement may be obtained in more cases if the dose is increased to 6mg per day.”

Wednesday, June 07, 2006

Alzheimer's vaccine passes first test

Biosingularity » Blog Archive » Study Reveals New Vaccine Reverses Memory Loss
magine an Alzheimer's patient receiving a vaccine made of specialized blood cells and then showing a much- improved memory. Also, imagine that vaccine having no side effects and needing to be given only occasionally.

Researchers at the Johnnie B. Byrd, Sr. Alzheimer's Center & Research Institute in Tampa, Florida, have not only imagined these things, they have actually developed such a vaccine that they show reverses memory loss in Alzheimer's mice.

In a study published this week in the journal, Neurobiology of Disease, researchers report that tests of the new vaccine on mice shows promise of reversing memory loss and seriously slowing the effects of Alzheimer's on patients. The groundbreaking research was done by investigators from the Byrd Alzheimer's Institute, the University of South Florida, and University of California Riverside.

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Tuesday, March 07, 2006

New Scientist Features - Get ready for 24-hour living

New Scientist Features - Get ready for 24-hour living: "'The more we understand about the body's 24-hour clock the more we will be able to override it,' says Russell Foster, a circadian biologist at Imperial College London. 'In 10 to 20 years we'll be able to pharmacologically turn sleep off. Mimicking sleep will take longer, but I can see it happening.' Foster envisages a world where it's possible, or even routine, for people to be active for 22 hours a day and sleep for two. It is not a world that everyone likes the sound of. 'I think that would be the most hideous thing to happen to society,' says Neil Stanley, head of sleep research at the Human Psychopharmacology Research Unit in the University of Surrey, UK. But most sleep researchers agree that it is inevitable.

If that sounds unlikely, think about what is already here. Modafinil has made it possible to have 48 hours of continuous wakefulness with few, if any, ill effects. New classes of sleeping pills are on the horizon that promise to deliver sleep that is deeper and more refreshing than the real thing. Further down the line are even more radical interventions - wakefulness promoters that can safely abolish sleep for several days at a stretch, and sleeping pills that deliver what feels like 8 hours of sleep in half the time. Nor is it all about drugs: one research team even talks about developing a wearable electrical device that can wake your brain up at the flick of a switch.

To some degree, we are already adept at controlling sleep. Most people in full-time work deprive themselves of sleep during the week, deliberately or otherwise, and catch up at the weekend. We often augment our sleep-suppressing powers with caffeine, nicotine or illegal stimulants such as cocaine and amphetamines. We are also highly dependent on substances that help us sleep. According to some estimates, 75 per cent of adults suffer at least one symptom of a sleep problem a few nights a week or more. In 1"